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Structural characterization of a human Fc fragment engineered for lack of effector functions
The first three-dimensional structure of a human Fc fragment genetically engineered for the elimination of its ability to mediate antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity is reported. When introduced into the lower hinge and C(H)2 domain of human IgG1 molec...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
International Union of Crystallography
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2467532/ https://ncbi.nlm.nih.gov/pubmed/18560159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444908007877 |
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