Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP–E2F1–DNA damage response pathway axis

The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes‐associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evidence indicate that YAP activates transcriptional...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Oku, Yusuke, Nishiya, Naoyuki, Tazawa, Takaaki, Kobayashi, Takaya, Umezawa, Nanami, Sugawara, Yasuyo, Uehara, Yoshimasa
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986022/
https://ncbi.nlm.nih.gov/pubmed/29928579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12440
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