Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

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Bibliografski detalji
Izdano u:FEBS Open Bio
Glavni autori: Oku, Yusuke, Nishiya, Naoyuki, Shito, Toshiya, Yamamoto, Reiichiro, Yamamoto, Yasufumi, Oyama, Chihiro, Uehara, Yoshimasa
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2015
Teme:
Research article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506957/
https://ncbi.nlm.nih.gov/pubmed/26199863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.06.007
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