Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

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Foilsithe in:FEBS Open Bio
Main Authors: Oku, Yusuke, Nishiya, Naoyuki, Shito, Toshiya, Yamamoto, Reiichiro, Yamamoto, Yasufumi, Oyama, Chihiro, Uehara, Yoshimasa
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2015
Ábhair:
Research article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506957/
https://ncbi.nlm.nih.gov/pubmed/26199863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.06.007
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