Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

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Udgivet i:FEBS Open Bio
Main Authors: Oku, Yusuke, Nishiya, Naoyuki, Shito, Toshiya, Yamamoto, Reiichiro, Yamamoto, Yasufumi, Oyama, Chihiro, Uehara, Yoshimasa
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506957/
https://ncbi.nlm.nih.gov/pubmed/26199863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.06.007
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