Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

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發表在:FEBS Open Bio
Main Authors: Oku, Yusuke, Nishiya, Naoyuki, Shito, Toshiya, Yamamoto, Reiichiro, Yamamoto, Yasufumi, Oyama, Chihiro, Uehara, Yoshimasa
格式: Artigo
語言:Inglês
出版: Elsevier 2015
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Research article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506957/
https://ncbi.nlm.nih.gov/pubmed/26199863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.06.007
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