Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP–E2F1–DNA damage response pathway axis

The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes‐associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evidence indicate that YAP activates transcriptional...

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Pubblicato in:FEBS Open Bio
Autori principali: Oku, Yusuke, Nishiya, Naoyuki, Tazawa, Takaaki, Kobayashi, Takaya, Umezawa, Nanami, Sugawara, Yasuyo, Uehara, Yoshimasa
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986022/
https://ncbi.nlm.nih.gov/pubmed/29928579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12440
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