MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis

The Hippo pathway plays a pivotal role in tissue homeostasis and tumor suppression. YAP and TAZ are downstream effectors of the Hippo pathway, and their activities are tightly suppressed by phosphorylation-dependent cytoplasmic retention. However, the molecular mechanisms governing YAP/TAZ nuclear l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kim, Jiyoung, Kwon, Hyeryun, Shin, You Keun, Song, Gahyeon, Lee, Taebok, Kim, Youngeun, Jeong, Wonyoung, Lee, Ukjin, Zhang, Xianglan, Nam, Gilyeong, Jeung, Hei-Cheul, Kim, Wantae, Jho, Eek-hoon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306791/
https://ncbi.nlm.nih.gov/pubmed/32482852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917969117
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