Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents

Accurate chromosome segregation is vital for cell viability. Many cancer cells show chromosome instability (CIN) due to aberrant expression of the genes involved in chromosome segregation. The induction of massive chromosome segregation errors in such cancer cells by small molecule inhibitors is an...

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Bibliographic Details
Main Authors: Oku, Yusuke, Tareyanagi, Chiaki, Takaya, Shinichi, Osaka, Sayaka, Ujiie, Haruki, Yoshida, Kentaro, Nishiya, Naoyuki, Uehara, Yoshimasa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958508/
https://ncbi.nlm.nih.gov/pubmed/24642638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092402
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