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ROCK1 and LIMK2 Interact in Spread but Not Blebbing Cancer Cells

Cancer cells migrating within a 3D microenvironment are able to adopt either a mesenchymal or amoeboid mode of migration. Amoeboid migration is characterised by membrane blebbing that is dependent on the Rho effectors, ROCK1/2. We identify LIMK2 as the preferred substrate for ROCK1 but find that LIM...

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Bibliografski detalji
Glavni autori: Shea, Kerry F., Wells, Claire M., Garner, Andrew P., Jones, Gareth E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561063/
https://ncbi.nlm.nih.gov/pubmed/18852895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003398
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