A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

Genome-wide association studies (GWASs) and functional genomics approaches implicate enhancer disruption in islet dysfunction and type 2 diabetes (T2D) risk. We applied genetic fine-mapping and functional (epi)genomic approaches to a T2D- and proinsulin-associated 15q22.2 locus to identify a most li...

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Bibliografski detalji
Izdano u:Am J Hum Genet
Glavni autori: Kycia, Ina, Wolford, Brooke N., Huyghe, Jeroen R., Fuchsberger, Christian, Vadlamudi, Swarooparani, Kursawe, Romy, Welch, Ryan P., Albanus, Ricardo d’Oliveira, Uyar, Asli, Khetan, Shubham, Lawlor, Nathan, Bolisetty, Mohan, Mathur, Anubhuti, Kuusisto, Johanna, Laakso, Markku, Ucar, Duygu, Mohlke, Karen L., Boehnke, Michael, Collins, Francis S., Parker, Stephen C.J., Stitzel, Michael L.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985342/
https://ncbi.nlm.nih.gov/pubmed/29625024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.02.020
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