A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

Genome-wide association studies (GWASs) and functional genomics approaches implicate enhancer disruption in islet dysfunction and type 2 diabetes (T2D) risk. We applied genetic fine-mapping and functional (epi)genomic approaches to a T2D- and proinsulin-associated 15q22.2 locus to identify a most li...

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Publicado no:Am J Hum Genet
Main Authors: Kycia, Ina, Wolford, Brooke N., Huyghe, Jeroen R., Fuchsberger, Christian, Vadlamudi, Swarooparani, Kursawe, Romy, Welch, Ryan P., Albanus, Ricardo d’Oliveira, Uyar, Asli, Khetan, Shubham, Lawlor, Nathan, Bolisetty, Mohan, Mathur, Anubhuti, Kuusisto, Johanna, Laakso, Markku, Ucar, Duygu, Mohlke, Karen L., Boehnke, Michael, Collins, Francis S., Parker, Stephen C.J., Stitzel, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985342/
https://ncbi.nlm.nih.gov/pubmed/29625024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.02.020
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