Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Store-operated Orai1 channels are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca(2+) sensor STIM1 to cytoplasmic sites on Orai1. Although atomic-level details of Orai structure, including the pore and putative ligand binding domains, are resolved, h...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yeung, Priscilla S.-W., Yamashita, Megumi, Ing, Christopher E., Pomès, Régis, Freymann, Douglas M., Prakriya, Murali
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984495/
https://ncbi.nlm.nih.gov/pubmed/29760086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718373115
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