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The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels
Ca(2+) release-activated Ca(2+) (CRAC) channels are activated through a mechanism wherein depletion of intracellular calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690689/ https://ncbi.nlm.nih.gov/pubmed/23613525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.250456 |
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