The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

Ca(2+) release-activated Ca(2+) (CRAC) channels are activated through a mechanism wherein depletion of intracellular calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping...

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Bibliographic Details
Main Authors: McNally, Beth A, Somasundaram, Agila, Jairaman, Amit, Yamashita, Megumi, Prakriya, Murali
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2013
Subjects:
Molecular and Cellular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690689/
https://ncbi.nlm.nih.gov/pubmed/23613525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.250456
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