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Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating
Store-operated Orai1 channels are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca(2+) sensor STIM1 to cytoplasmic sites on Orai1. Although atomic-level details of Orai structure, including the pore and putative ligand binding domains, are resolved, h...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984495/ https://ncbi.nlm.nih.gov/pubmed/29760086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718373115 |
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