The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Store-operated Orai1 channels regulate a wide range of cellular functions from gene expression to cell proliferation. Previous studies have shown that gating of Orai1 channels is regulated by the outer pore residues V102 and F99, which together function as a hydrophobic gate to block ion conduction...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Yamashita, Megumi, Ing, Christopher E., Yeung, Priscilla See-Wai, Maneshi, Mohammad M., Pomès, Régis, Prakriya, Murali
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034092/
https://ncbi.nlm.nih.gov/pubmed/31816637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912397
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