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A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 channels via its sulfur-aromatic interactions with...
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| Publié dans: | eLife |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7679135/ https://ncbi.nlm.nih.gov/pubmed/33124982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60751 |
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