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Spatial mutation patterns as markers of early colorectal tumor cell mobility

A growing body of evidence suggests that a subset of human cancers grows as single clonal expansions. In such a nearly neutral evolution scenario, it is possible to infer the early ancestral tree of a full-grown tumor. We hypothesized that early tree reconstruction can provide insights into the mobi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ryser, Marc D., Min, Byung-Hoon, Siegmund, Kimberly D., Shibata, Darryl
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984490/
https://ncbi.nlm.nih.gov/pubmed/29760052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716552115
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