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High DNA Methylation Pattern Intratumoral Diversity Implies Weak Selection in Many Human Colorectal Cancers

BACKGROUND: It is possible to infer the past of populations by comparing genomes between individuals. In general, older populations have more genomic diversity than younger populations. The force of selection can also be inferred from population diversity. If selection is strong and frequently elimi...

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Bibliographic Details
Main Authors: Siegmund, Kimberly D., Marjoram, Paul, Tavaré, Simon, Shibata, Darryl
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125304/
https://ncbi.nlm.nih.gov/pubmed/21738754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021657
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