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High DNA Methylation Pattern Intratumoral Diversity Implies Weak Selection in Many Human Colorectal Cancers

BACKGROUND: It is possible to infer the past of populations by comparing genomes between individuals. In general, older populations have more genomic diversity than younger populations. The force of selection can also be inferred from population diversity. If selection is strong and frequently elimi...

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Hlavní autoři: Siegmund, Kimberly D., Marjoram, Paul, Tavaré, Simon, Shibata, Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125304/
https://ncbi.nlm.nih.gov/pubmed/21738754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021657
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