Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis

Glycosylation is a prominent strategy to optimize the pharmacokinetic and pharmacodynamic properties of drug-like small-molecule scaffolds by modulating their solubility, stability, bioavailability, and bioactivity. Glycosyltransferases applicable for “sugarcoating” various small-molecule acceptors...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Xie, Linan, Zhang, Liwen, Wang, Chen, Wang, Xiaojing, Xu, Ya-ming, Yu, Hefen, Wu, Ping, Li, Shenglan, Han, Lida, Gunatilaka, A. A. Leslie, Wei, Xiaoyi, Lin, Min, Molnár, István, Xu, Yuquan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984488/
https://ncbi.nlm.nih.gov/pubmed/29760061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716046115
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