Rational Reprogramming of O-Methylation Regioselectivity for Combinatorial Biosynthetic Tailoring of Benzenediol Lactone Scaffolds

[Image: see text] O-Methylation modulates the pharmacokinetic and pharmacodynamic (PK/PD) properties of small-molecule natural products, affecting their bioavailability, stability, and binding to targets. Diversity-oriented combinatorial biosynthesis of new chemical entities for drug discovery and o...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Wang, Xiaojing, Wang, Chen, Duan, Lixin, Zhang, Liwen, Liu, Hang, Xu, Ya-ming, Liu, Qingpei, Mao, Tonglin, Zhang, Wei, Chen, Ming, Lin, Min, Gunatilaka, A. A. Leslie, Xu, Yuquan, Molnár, István
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416077/
https://ncbi.nlm.nih.gov/pubmed/30767524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12967
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