Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons

Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-or...

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Detaylı Bibliyografya
Yayımlandı:Org Lett
Asıl Yazarlar: Bai, Jing, Lu, Yuanyuan, Xu, Ya-ming, Zhang, Wei, Chen, Ming, Lin, Min, Leslie Gunatilaka, A. A., Xu, Yuquan, Molnár, István
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332125/
https://ncbi.nlm.nih.gov/pubmed/26934205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b00110
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