Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons

Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-or...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Bai, Jing, Lu, Yuanyuan, Xu, Ya-ming, Zhang, Wei, Chen, Ming, Lin, Min, Leslie Gunatilaka, A. A., Xu, Yuquan, Molnár, István
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332125/
https://ncbi.nlm.nih.gov/pubmed/26934205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b00110
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