Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons

Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-or...

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Gepubliceerd in:Org Lett
Hoofdauteurs: Bai, Jing, Lu, Yuanyuan, Xu, Ya-ming, Zhang, Wei, Chen, Ming, Lin, Min, Leslie Gunatilaka, A. A., Xu, Yuquan, Molnár, István
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332125/
https://ncbi.nlm.nih.gov/pubmed/26934205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b00110
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