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Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting
For decades oncogenic RAS proteins were considered undruggable due to a lack of accessible binding pockets on the protein surfaces. Seminal early research in RAS biology uncovered the basic paradigm of post-translational isoprenylation of RAS polypeptides, typically with covalent attachment of a far...
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| Publicado no: | Semin Cancer Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984110/ https://ncbi.nlm.nih.gov/pubmed/29203271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2017.11.021 |
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