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Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B
Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transc...
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| 發表在: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5983322/ https://ncbi.nlm.nih.gov/pubmed/29757189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96915 |
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