Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B

Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transc...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Al Labban, Dania, Jo, Seung-Hee, Ostano, Paola, Saglietti, Chiara, Bongiovanni, Massimo, Panizzon, Renato, Dotto, G. Paolo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983322/
https://ncbi.nlm.nih.gov/pubmed/29757189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96915
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