The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome activation are not fully understood. Here, we r...

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Publicado en:Sci Rep
Autores principales: Rodrigue-Gervais, Ian Gaël, Doiron, Karine, Champagne, Claudia, Mayes, Lindsey, Leiva-Torres, Gabriel André, Vanié, Paulin, Douglas, Todd, Vidal, Silvia M., Alnemri, Emad S., Saleh, Maya
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981608/
https://ncbi.nlm.nih.gov/pubmed/29855523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26603-1
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