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The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome activation are not fully understood. Here, we r...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rodrigue-Gervais, Ian Gaël, Doiron, Karine, Champagne, Claudia, Mayes, Lindsey, Leiva-Torres, Gabriel André, Vanié, Paulin, Douglas, Todd, Vidal, Silvia M., Alnemri, Emad S., Saleh, Maya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981608/
https://ncbi.nlm.nih.gov/pubmed/29855523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26603-1
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