Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

BACKGROUND AND PURPOSE: Patients with irritable bowel syndrome suffer from chronic visceral pain (CVP) and limited analgesic therapeutic options are currently available. We have shown that α‐conotoxin Vc1.1 induced activation of GABA(B) receptors on the peripheral endings of colonic afferents and re...

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Publicado en:Br J Pharmacol
Autores principales: Castro, Joel, Grundy, Luke, Deiteren, Annemie, Harrington, Andrea M, O'Donnell, Tracey, Maddern, Jessica, Moore, Jessi, Garcia‐Caraballo, Sonia, Rychkov, Grigori Y, Yu, Rilei, Kaas, Quentin, Craik, David J, Adams, David J, Brierley, Stuart M
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Themed Section: Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980271/
https://ncbi.nlm.nih.gov/pubmed/29194563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14115
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