Blockade of Neuronal α7-nAChR by α-Conotoxin ImI Explained by Computational Scanning and Energy Calculations

α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission. They are also used as neurochemical tools to study nAChR physiology and are being evaluated as drug leads to treat various neuronal disorders. A numb...

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Bibliographic Details
Main Authors: Yu, Rilei, Craik, David J., Kaas, Quentin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048385/
https://ncbi.nlm.nih.gov/pubmed/21390272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002011
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