Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

BACKGROUND AND PURPOSE: Patients with irritable bowel syndrome suffer from chronic visceral pain (CVP) and limited analgesic therapeutic options are currently available. We have shown that α‐conotoxin Vc1.1 induced activation of GABA(B) receptors on the peripheral endings of colonic afferents and re...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Castro, Joel, Grundy, Luke, Deiteren, Annemie, Harrington, Andrea M, O'Donnell, Tracey, Maddern, Jessica, Moore, Jessi, Garcia‐Caraballo, Sonia, Rychkov, Grigori Y, Yu, Rilei, Kaas, Quentin, Craik, David J, Adams, David J, Brierley, Stuart M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Themed Section: Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980271/
https://ncbi.nlm.nih.gov/pubmed/29194563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14115
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