α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA(B) receptors

OBJECTIVE: α-Conotoxin Vc1.1 is a small disulfide-bonded peptide from the venom of the marine cone snail Conus victoriae. Vc1.1 has antinociceptive actions in animal models of neuropathic pain, but its applicability to inhibiting human dorsal root ganglion (DRG) neuroexcitability and reducing chroni...

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Enregistré dans:
Détails bibliographiques
Publié dans:Gut
Auteurs principaux: Castro, Joel, Harrington, Andrea M, Garcia-Caraballo, Sonia, Maddern, Jessica, Grundy, Luke, Zhang, Jingming, Page, Guy, Miller, Paul E, Craik, David J, Adams, David J, Brierley, Stuart M
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2017
Sujets:
Neurogastroenterology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532460/
https://ncbi.nlm.nih.gov/pubmed/26887818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310971
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