α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA(B) receptors

OBJECTIVE: α-Conotoxin Vc1.1 is a small disulfide-bonded peptide from the venom of the marine cone snail Conus victoriae. Vc1.1 has antinociceptive actions in animal models of neuropathic pain, but its applicability to inhibiting human dorsal root ganglion (DRG) neuroexcitability and reducing chroni...

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Udgivet i:Gut
Main Authors: Castro, Joel, Harrington, Andrea M, Garcia-Caraballo, Sonia, Maddern, Jessica, Grundy, Luke, Zhang, Jingming, Page, Guy, Miller, Paul E, Craik, David J, Adams, David J, Brierley, Stuart M
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2017
Fag:
Neurogastroenterology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532460/
https://ncbi.nlm.nih.gov/pubmed/26887818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310971
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