Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

BACKGROUND AND PURPOSE: Patients with irritable bowel syndrome suffer from chronic visceral pain (CVP) and limited analgesic therapeutic options are currently available. We have shown that α‐conotoxin Vc1.1 induced activation of GABA(B) receptors on the peripheral endings of colonic afferents and re...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Castro, Joel, Grundy, Luke, Deiteren, Annemie, Harrington, Andrea M, O'Donnell, Tracey, Maddern, Jessica, Moore, Jessi, Garcia‐Caraballo, Sonia, Rychkov, Grigori Y, Yu, Rilei, Kaas, Quentin, Craik, David J, Adams, David J, Brierley, Stuart M
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
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Themed Section: Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980271/
https://ncbi.nlm.nih.gov/pubmed/29194563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14115
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