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Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation
Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of prostate cancer displaying hyperactive Akt. PTEN-defic...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980228/ https://ncbi.nlm.nih.gov/pubmed/29687779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32213 |
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