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Systemic Akt1 deletion after tumor onset in p53(−/−) mice increases lifespan and regresses thymic lymphoma emulating p53 restoration

Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform, could regress cancer progression in cancers that are not driven by Akt activation. We systemically deleted Akt1, after tumor onset, in p53(−/−) mice, which develop tumors indepen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Yu, Wan-Ni, Nogueira, Veronique, Sobhakumari, Arya, Patra, Krushna C., Bhaskar, Prashanth T., Hay, Nissim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526157/
https://ncbi.nlm.nih.gov/pubmed/26190111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.057
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