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Systemic Akt1 deletion after tumor onset in p53(−/−) mice increases lifespan and regresses thymic lymphoma emulating p53 restoration
Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform, could regress cancer progression in cancers that are not driven by Akt activation. We systemically deleted Akt1, after tumor onset, in p53(−/−) mice, which develop tumors indepen...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526157/ https://ncbi.nlm.nih.gov/pubmed/26190111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.057 |
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