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Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors

Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by targeting orthodox agonist sites because of high sequence similarity of this binding pocket among different subunits. Re...

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Pubblicato in:Br J Pharmacol
Autori principali: Wang, Jingyi, Lindstrom, Jon
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980197/
https://ncbi.nlm.nih.gov/pubmed/28199738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13745
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