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Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors
Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by targeting orthodox agonist sites because of high sequence similarity of this binding pocket among different subunits. Re...
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| Udgivet i: | Br J Pharmacol |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980197/ https://ncbi.nlm.nih.gov/pubmed/28199738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13745 |
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