Discovery of an intrasubunit nicotinic acetylcholine receptor–binding site for the positive allosteric modulator Br-PBTC

Nicotinic acetylcholine receptor (nAChR) ligands that lack agonist activity but enhance activation in the presence of an agonist are called positive allosteric modulators (PAMs). nAChR PAMs have therapeutic potential for the treatment of nicotine addiction and several neuropsychiatric disorders. PAM...

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Publicat a:J Biol Chem
Autors principals: Norleans, Jack, Wang, Jingyi, Kuryatov, Alexander, Leffler, Abba, Doebelin, Christelle, Kamenecka, Theodore M., Lindstrom, Jon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690704/
https://ncbi.nlm.nih.gov/pubmed/31221718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006253
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