Discovery of an intrasubunit nicotinic acetylcholine receptor–binding site for the positive allosteric modulator Br-PBTC

Nicotinic acetylcholine receptor (nAChR) ligands that lack agonist activity but enhance activation in the presence of an agonist are called positive allosteric modulators (PAMs). nAChR PAMs have therapeutic potential for the treatment of nicotine addiction and several neuropsychiatric disorders. PAM...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Norleans, Jack, Wang, Jingyi, Kuryatov, Alexander, Leffler, Abba, Doebelin, Christelle, Kamenecka, Theodore M., Lindstrom, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690704/
https://ncbi.nlm.nih.gov/pubmed/31221718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006253
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