An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors

Neuronal nicotinic acetylcholine receptors containing α4, β2, and sometimes other subunits (α4β2* nAChRs) regulate addictive and other behavioral effects of nicotine. These nAChRs exist in several stoichiometries, typically with two high affinity acetylcholine (ACh) binding sites at the interface of...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Jingyi, Kuryatov, Alexander, Sriram, Aarati, Jin, Zhuang, Kamenecka, Theodore M., Kenny, Paul J., Lindstrom, Jon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447965/
https://ncbi.nlm.nih.gov/pubmed/25869137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.646786
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