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Differential α4(+)/(−)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms
Two α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) isoforms exist with (α4)(2)(β2)(3) and (α4)(3)(β2)(2) subunit stoichiometries and high versus low agonist sensitivities (HS and LS), respectively. Both isoforms contain a pair of α4(+)/(−)β2 agonist-binding sites. The LS isoform also contains a...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732226/ https://ncbi.nlm.nih.gov/pubmed/26644472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684373 |
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