The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)(3)(β2)(2) Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)(2)(β2)(3) Subtype

Selected nicotinic agonists were used to activate and desensitize high-sensitivity (HS) (α4)(2)(β2)(3)) or low-sensitivity (LS) (α4)(3)(β2)(2)) isoforms of human α4β2-nicotinic acetylcholine receptors (nAChRs). Function was assessed using (86)Rb(+) efflux in a stably transfected SH-EP1-hα4β2 human e...

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Bibliographische Detailangaben
Hauptverfasser: Eaton, J. Brek, Lucero, Linda M., Stratton, Harrison, Chang, Yongchang, Cooper, John F., Lindstrom, Jon M., Lukas, Ronald J., Whiteaker, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
Schlagworte:
Neuropharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868879/
https://ncbi.nlm.nih.gov/pubmed/24190916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208389
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