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Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures

Sleep-related hypermotor epilepsy (SHE) is a group of seizure disorders prominently associated with mutations in nicotinic acetylcholine receptors (nAChR). The most prevalent central nervous system nAChR subtype contains α4 and β2 subunits, in two ratios. (α4β2)(2)β2-nAChR have high agonist sensitiv...

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Vydáno v:PLoS One
Hlavní autoři: Weltzin, Maegan M., George, Andrew A., Lukas, Ronald J., Whiteaker, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928491/
https://ncbi.nlm.nih.gov/pubmed/33657187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247825
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