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Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms

Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist sensitivity (HS-(α4β2)(2)β2- and LS-(α4β2)(2)α4-nAChR). Both isoforms exhibit similar macroscopic potency and efficacy values at low acetylcholine (ACh...

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Publicat a:PLoS One
Autors principals: Weltzin, Maegan M., George, Andrew A., Lukas, Ronald J., Whiteaker, Paul
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405073/
https://ncbi.nlm.nih.gov/pubmed/30845161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213143
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