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The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding
The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For the...
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| Publicado en: | Int J Mol Sci |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5979565/ https://ncbi.nlm.nih.gov/pubmed/29652801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19041184 |
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