Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers

The protein family of small GTPases controls cellular processes by acting as a binary switch between an active and an inactive state. The most prominent family members are H-Ras, N-Ras, and K-Ras isoforms, which are highly related and frequently mutated in cancer. Bisphenols are widespread in modern...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Schöpel, Miriam, Shkura, Oleksandr, Seidel, Jana, Kock, Klaus, Zhong, Xueyin, Löffek, Stefanie, Helfrich, Iris, Bachmann, Hagen S., Scherkenbeck, Jürgen, Herrmann, Christian, Stoll, Raphael
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979466/
https://ncbi.nlm.nih.gov/pubmed/29642594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19041133
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