The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

BACKGROUND: Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several cellular processes such as cytokinesis and actin-cytoskeletal rearrangement. The...

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Vydáno v:BMC Mol Cell Biol
Hlavní autoři: Dicks, Markus, Kock, Gerd, Kohl, Bastian, Zhong, Xueyin, Pütz, Stefanie, Heumann, Rolf, Erdmann, Kai S., Stoll, Raphael
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615252/
https://ncbi.nlm.nih.gov/pubmed/31286859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-019-0203-6
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