The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

BACKGROUND: Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several cellular processes such as cytokinesis and actin-cytoskeletal rearrangement. The...

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Bibliografiska uppgifter
I publikationen:BMC Mol Cell Biol
Huvudupphovsmän: Dicks, Markus, Kock, Gerd, Kohl, Bastian, Zhong, Xueyin, Pütz, Stefanie, Heumann, Rolf, Erdmann, Kai S., Stoll, Raphael
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615252/
https://ncbi.nlm.nih.gov/pubmed/31286859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-019-0203-6
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