HIV-1 Nef impairs MHC class II antigen presentation and surface expression

HIV-1-infected cells can avoid cytotoxic T lymphocyte killing by Nef-mediated down-regulation of surface MHC I. Here, we show that HIV-1 Nef inhibits MHC II restricted peptide presentation to specific T cells and thus may affect the induction of antiviral immune responses. Nef mediates this effect b...

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Bibliografske podrobnosti

izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Stumptner-Cuvelette, Pamela, Morchoisne, Stephanie, Dugast, Marc, Le Gall, Sylvie, Raposo, Graça, Schwartz, Olivier, Benaroch, Philippe
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2001
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC59782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11593029/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221256498
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