Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles

Recently, it has been demonstrated that the human immunodeficiency virus type 1 (HIV-1) Nef from laboratory strains down-modulates cell surface expression of mature major histocompatibility complex class II (MHC-II) molecules, while up-regulating surface expression of the invariant chain (Ii) associ...

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Detalhes bibliográficos
Main Authors: Schindler, Michael, Würfl, Stephanie, Benaroch, Philippe, Greenough, Thomas C., Daniels, Rod, Easterbrook, Philippa, Brenner, Matthias, Münch, Jan, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC228419/
https://ncbi.nlm.nih.gov/pubmed/12970439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10548-10556.2003
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