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Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles

Recently, it has been demonstrated that the human immunodeficiency virus type 1 (HIV-1) Nef from laboratory strains down-modulates cell surface expression of mature major histocompatibility complex class II (MHC-II) molecules, while up-regulating surface expression of the invariant chain (Ii) associ...

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Udgivet i:J Virol
Principais autores: Schindler, Michael, Würfl, Stephanie, Benaroch, Philippe, Greenough, Thomas C., Daniels, Rod, Easterbrook, Philippa, Brenner, Matthias, Münch, Jan, Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228419/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12970439/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.19.10548-10556.2003
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