Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment

A tripartite cancer vaccine candidate, containing a quaternary amino acid (α-methylserine) in the most immunogenic domain of MUC1, has been synthesized and examined for antigenic properties in transgenic mice. The vaccine which is glycosylated with GalNAc at the unnatural amino acid, was capable of...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Martínez-Sáez, Nuria, Supekar, Nitin T., Wolfert, Margreet A., Bermejo, Iris A., Hurtado-Guerrero, Ramón, Asensio, Juan L., Jiménez-Barbero, Jesús, Busto, Jesús H., Avenoza, Alberto, Boons, Geert-Jan, Peregrina, Jesús M., Corzana, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977504/
https://ncbi.nlm.nih.gov/pubmed/29910919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04039f
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