Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

Native flexibly linked (NFL) HIV-1 envelope glycoprotein (Env) trimers are cleavage-independent and display a native-like, well-folded conformation that preferentially displays broadly neutralizing determinants. The NFL platform simplifies large-scale production of Env by eliminating the need to co-...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bale, Shridhar, Martiné, Alexandra, Wilson, Richard, Behrens, Anna-Janina, Le Fourn, Valérie, de Val, Natalia, Sharma, Shailendra K., Tran, Karen, Torres, Jonathan L., Girod, Pierre-Alain, Ward, Andrew B., Crispin, Max, Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976746/
https://ncbi.nlm.nih.gov/pubmed/29881382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01116
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