PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver

3,3′,4,4′,5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through a wide array of noncarcinogenic effects, including metabolic syndrome, wasting, and nonalcoholic fatty-liver disease. Previously, we reported decreases in the transcription of several enzymes involved in gluconeoge...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Gadupudi, Gopi S, Elser, Benjamin A, Sandgruber, Fabian A, Li, Xueshu, Gibson-Corley, Katherine N, Robertson, Larry W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Pcb126 and Altered Signaled Transduction in Liver
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974782/
https://ncbi.nlm.nih.gov/pubmed/29474705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy041
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