Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and l...

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Publicado no:Sci Rep
Main Authors: Siddiqui, Farid Ahmad, Prakasam, Gopinath, Chattopadhyay, Shilpi, Rehman, Asad Ur, Padder, Rayees Ahmad, Ansari, Mohammad Afaque, Irshad, Rasha, Mangalhara, Kailash, Bamezai, Rameshwar N. K., Husain, Mohammad, Ali, Syed Mansoor, Iqbal, Mohammad Askandar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974195/
https://ncbi.nlm.nih.gov/pubmed/29844464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25524-3
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