Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer

Cancer cells rewire metabolism to meet biosynthetic and energetic demands. The characteristic increase in glycolysis, i.e., Warburg effect, now considered as a hallmark, supports cancer in various ways. To attain such metabolic reshuffle, cancer cells preferentially re-express the M2 isoform of pyru...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Prakasam, Gopinath, Iqbal, Mohammad Askandar, Bamezai, Rameshwar N. K., Mazurek, Sybille
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808394/
https://ncbi.nlm.nih.gov/pubmed/29468140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00022
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