Pyruvate kinase M knockdown–induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival

Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered critical for aerobic glycolysis in cancer cells. However, our results reported here indicate co-expression of PKM1 and PKM2 and their possib...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Prakasam, Gopinath, Singh, Rajnish Kumar, Iqbal, Mohammad Askandar, Saini, Sunil Kumar, Tiku, Ashu Bhan, Bamezai, Rameshwar N. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602412/
https://ncbi.nlm.nih.gov/pubmed/28778925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.791343
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